kw10

Decomposition plots are empty

3

I'm running sigprofileExtractor (v1.1.7, python 3.9.2) and get all expected outputs, except the *_Decomposition_Plots.pdf are all empty. I get 3 SBS signatures and 2 ID signatures that are decomposed to...

Ploidy and purity estimates

1

Following the example usage in the vignette, I retrieve the purity and ploidy estimates: ``` fit = emcncf(oo) fit$purity fit$ploidy ``` For some samples I get "75%" preceding the value....

Samples with high mutation rates

4

Hello I was wondering if DISCOVER is suitable for samples with high mutation rates (e.g. skin tumour samples with UV mutational signatures; ~5-10 mutations/Mb). I have a cohort that seems...

p-value and q-values are the same for top hit

4

I am using the latest R version and I only have 1 mutually exclusive pair; the p and q values are the same. I am using fdr method DBH. I...

I have some tumours that have multiple somatic missense or indels in the same gene. For example in ARID1A (below) one sample has 2 missense mutations and the other has...