Ying-yuan Xie

run without KO sample

1

Hi Xpore team! I' d like to know if it is possible to run Xpore without a control sample (like KO sample), and this is the case where I only...

**Use case** A clear and concise description of what the use case is. For example: my data is from [...] **Describe the problem** A clear and concise description of what...

Hi nanopolish team! I wonder if there are any settings to prevent skip as showed below when using nanopolish eventalign? As you know, eventalign assigns events to bases accoding to...

Hi Tombo Team! I want to know the exact meaning of fit-global-scale parameter when using Tombo resquiggle？and what it is used for? and when I should use ? I used...

Hi! I want to know when a read is multi aligned, which alignment will tombo choose when resquiggle? primary alignment? or a higher mapping quality one?

about tombo resquiggle

2

Hi！as we know that the current of RNA sample in the nanopore is determined by 5 continuous bases, however, in tombo resquiggle result event table (as showed below), one event...

about RRACH sites

3

Hi developer！As your paper and github show Epinano trained the SVM model use 5-mer that contained only one A, should I discard the kmer in the results file with more...

avoid skip when using f5c eventalign

8

Hi f5C team! I wonder if there are any settings to avoid event skip when using f5c eventalign? I found not all bases in reference would have event in f5c...

how bonito normalize raw signals when save-ctc

2

Hi bonito team! I want to know how bonito normalize raw signals! I noticed that in the chunks.npy, the signal seem to be normalized to (-1, 1). Does bonito normalize...

Hi Megalodon team! I want know what the neural network output from Guppy exactly is?