Reed A. Cartwright

I think something like this would work using ideas from TEST_CASE_FIXTURE and TEST_CASE_CLASS: ``` // Implementation of TEST_CASE_FRIEND #define DOCTEST_IMPLEMENT_FRIEND(der, base, func, decorators) \ namespace { \ struct der :...

@kyleabeauchamp My student has been using a modified version of `lzbench` to look at compression of FASTA, VCF, GTF, etc. I'll have her look at `squash` as well. A programmer...

I think one could get a lot out of using Zstd over Zlib due to is faster compression and decompression speed. Here is a summary of our results for bcf,...

Have you ever experimented with the pre calculated dictionary abilities of zstd or brotli? I imagine that for some file types, including a pre calculated dictionary along with htslib/bgzip would...

Having a `bztd` with configurable block size would be super helpful for a lot of reasons. Just last week I was thinking it would be nice to have a `tabix`...

Definitely sounds like an interesting research project.

> After some consideration I have determined that I won't add support for non-Java versions. I don't have a way to get the necessary information first hand nor can I...

I've never used `##pedigreeDB` in my tools, only `##pedigree` tags. If I had to pick, I'd ditch the existing VCF/BCF header format and replace it with YAML front matter. Where...

Yeah, I figured that the typo would be the easiest to fix and the rest involves a massive update.

I am skeptical that cython would help us out here. The best candidate to be ported to Python is the Bash-based front end, and we don't need cython for that....