Sam Nicholls

Results 68 issues of Sam Nicholls

Currently, reweighting works pretty well, apart from cases like this: ![screenshot from 2017-02-06 12-47-45](https://cloud.githubusercontent.com/assets/1105722/22648079/c493bfec-ec6c-11e6-82b8-a2004c432664.png) We end up "spending" the observed GA's on the first few rounds of path finding. Leaving...

enhancement
question
idea

I've been trying to polish one of our mock community datasets with racon-gpu, but am seeing slow performance during the overlap alignment phase. ![Screenshot from 2019-10-23 09-06-45](https://user-images.githubusercontent.com/1105722/67376243-b3edcf00-f57b-11e9-9e28-29aaac96e2c0.png) I can see...

It could be worth investigating providing a mechanism for post-census functions to be called on the count matrix once a census has been completed. This could allow for a GCRatioStrategy...

enhancement
question

A [comment raised on a reddit post](https://www.reddit.com/r/bioinformatics/comments/4brslk/published_my_first_paper_well_appnote_goldilocks/d1fuenl) about Goldilocks points out that some of the operations performed by the tool might well serve as standalone tools to be used in...

enhancement
question

- Remove files that are not required for distribution - Ensure all options are set as needed - Remove reliance on terrible Makefile - Better options for compilation of documentation

enhancement
help wanted

**nope.fa** ``` >NO >OP ``` **nope.fa.idx** ``` NO 0 4 -1 -1 OP 0 8 -1 -1 ``` **nope.py** ``` python from goldilocks.goldilocks import Goldilocks from goldilocks.strategies import NucleotideCounterStrategy data...

bug