How can I use CellChat to analysis scRNA-seq and snRNA-seq data together?

[Jihong528]

Hello, thanks for developing CellChat~

Now, I have scRNA-seq and snRNA-seq in hand, and some celltypes are specificly in scRNA-seq data while some other in snRNA-seq, and I want to know the cell communication from celltypes in scRNA-seq to celltypes in snRNA-seq. And I am so confused that can I just combine the scRNA-seq matrix and snRNA-seq matrix, then run CellChat. But one problem is that the sequencing depth is different from scRNA-seq to snRNA-seq, and I don't know how to normalize the two data? Could you help me on it? Thanks very much.