Doing stats across two datasets in merged CellChat

[bayankizil]

Hello!

Thank you so much for developing this incredibly useful tool! I merged two datasets with the same cell types to compare signaling from cell type 1 (het) to cell type 2 and cell type 1 (wt) to cell type 2. In netVisualBubble, I can set the threshold of the p-value to identify significant interactions. However, can I do a statistical test using this tool to see whether there is a significant difference between the strength of a certain signaling communication across the two datasets?

[sqjin]

@bayankizil You can check the tutorial and there is one part we combine the differential expression analysis. The rankNet function also implement a statistical test by setting 'do.stat = TRUE'.