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Pseudo-likelihood optimization does not take pseudo-counts into account

Open htalibart opened this issue 6 years ago • 0 comments

Hello,

Since pseudo-likelihood is optimized on the MSA and not on the frequencies, pseudo-counts are not actually used (except for v* centering).

Do you plan on working on this in a new version ? Or do you think it simply cannot be fixed because of the nature of pseudo-likelihood optimization itself ?

Best regards

htalibart avatar Dec 20 '19 09:12 htalibart