PKPDsim
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ronkeizer
R library for simulation of PKPD models [DEPRECATED, see InsightRX/PKPDsim]
Hello everyone, I´m doing simulation studies with neratinib in different patients for my Master´s thesis and I got issues with the age as a covariate. The cmax is increasing with...
Hi Ron, many thanks for your PKPDsim package. I tried to simulate different regimens (increasing doses). Shall I run sim_ode for each regimen or is it possible to do it...
Hi I am working on antibiotic combination and would like to simulate two different PK models simultaneously to drive a PD model. I was wondering what is the best way...
Training
Hi Do you conduct any training / hands on that one can go through to get familiar using this package Thank you
Hi Ron, I am attempting to create a simulation with a simple two-compartment oral model. Although the model compiles, the simulation does not seem to recognize the dose, and my...
Trying and failing miserably. :) Using the premade model pk1_cmt_oral, I get this description: ODE definition: dAdt[1] = -KA*A[1];; dAdt[2] = KA*A[1] - (CL/V)*A[2];; ; Required parameters: KA, CL, V...
Hi Ron, Hope things are OK. I am tying to implement the F (bioav fraction) for an oral drug and I thought it is as simple as adding in the...
First of all, thank you for this wonderful tool ! Here is my issue : I wrote the following PD model (two bacterial subpopulations) ` new_ode_model( code = " KILLS...
cv_to_omega requires two lists of inputs. I would change the user guide section on variability from dat
Perhaps good to explicitly in the documentation of sim() (sim_ode) mention the scale of omega (i.e. variance) ?
