T follicular helper 1 cell, T follicular helper 2 cell, T follicular helper 17 cell

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While going through some of the cell population/marker names used by several 
HIPC centers, we came across the following ones which are not present in Cell 
Ontology. 

T follicular helper 1 cell      
T follicular helper 2 cell      
T follicular helper 17 cell 

published paper to reference that support these as populations:
http://www.ncbi.nlm.nih.gov/pubmed/24069401 

We propose those cell populations to be added in Cell Ontology.

Thanks
Dimitris Sarantis

Original issue reported on code.google.com by [email protected] on 20 Mar 2015 at 6:06

[addiehl]

These cell types have primarily been described in humans, but may exist in mice and other species as well so both general and human specific cell type classes are proposed.

General Terms to be added name: T follicular helper 1 cell definition: A T follicular helper cell capable of producing interferon-gamma. [PMID:24069401, PMID:31570752] synonym: TFH1 cell [exact] synonym: Tfh1 cell [exact] equivalent to: 'T follicular helper cell' and ('capable of' some 'interferon-gamma production') and ('has plasma membrane part' some 'C-X-C chemokine receptor type 3') comment: The CXCR3 marker seems to be a cross species marker for this cell type.

name: T follicular helper 2 cell definition: A T follicular helper cell capable of producing interleukin-4. [PMID:24069401] synonym: TFH2 cell [exact] synonym: Tfh2 cell [exact] equivalent to: 'T follicular helper cell' and ('capable of' some 'interleukin-4 production')

name: T follicular helper 17 cell definition: A T follicular helper cell capable of producing interleukin-17 (IL-17A). [PMID:24069401] synonym: TFH17 cell [exact] synonym: Tfh17 cell [exact] equivalent to: 'T follicular helper cell' and ('capable of' some 'interleukin 17')

Human Specific Terms name: T follicular helper 1 cell, human definition: A T follicular helper 1 cell in the human with the phenotype CXCR3-positive, CCR6-negative. [PMID:24069401] synonym: TFH1 cell [broad] synonym: Tfh1 cell [broad] synonym: TFH1 cell, human [exact] equivalent to: 'T follicular helper 1 cell' and ('has plasma membrane part' some 'C-X-C chemokine receptor type 3 (human)') and (lacks_plasma_membrane_part some 'C-C chemokine receptor type 6 (human)') and only_in_taxon some 'homo sapiens'

name: T follicular helper 2 cell, human definition: A T follicular helper 2 cell in the human with the phenotype CXCR3-negative, CCR6-negative. [PMID:24069401] synonym: TFH2 cell [broad] synonym: Tfh2 cell [broad] synonym: TFH2 cell, human [exact] equivalent to: 'T follicular helper 2 cell' and (lacks_plasma_membrane_part some 'C-X-C chemokine receptor type 3 (human)') and (lacks_plasma_membrane_part some 'C-C chemokine receptor type 6 (human)') and only_in_taxon some 'homo sapiens'

name: T follicular helper 17 cell, human definition: A T follicular helper 17 cell in the human with the phenotype CXCR3-negative, CCR6-positive. [PMID:24069401] synonym: TFH17 cell [broad] synonym: Tfh17 cell [broad] synonym: TFH17 cell, human [exact] equivalent to: 'T follicular helper 2 cell' and (lacks_plasma_membrane_part some 'C-X-C chemokine receptor type 3 (human)') and ('has plasma membrane part' some 'C-C chemokine receptor type 6 (human)') and only_in_taxon some 'homo sapiens'

Mouse Tfh1 [PMID:31570752, PMID:31455769], Tfh2, and Tfh17 cell type classes will be added at a future point, as evidence accumulates for their existence in mice.

Alex

[paolaroncaglia]

@addiehl tagging you please because of your latest comment. Can this ticket be closed, or do we need to add new terms? Thank you.

[addiehl]

We need to add new terms. 'in taxon' is the appropriate relation to use now.

[paolaroncaglia]

@addiehl

We need to add new terms. 'in taxon' is the appropriate relation to use now.

Thanks. I'll leave this ticket assigned to you.