immunogenomics
Mat::init(): requested size is too large; suggest to enable ARMA_64BIT_WORD
Running the below code on a large reference and run into the error in the title. Any ideas on a fix would be greatly appreciated,
set.seed(0) full_reference = symphony::buildReference( normalized_counts, metadata, vars = c('donor_id'), # variables to integrate over K = 100, # number of Harmony clusters verbose = TRUE, # verbose output do_umap = TRUE, # can set to FALSE if want to run umap separately later do_normalize = FALSE, # set to TRUE if input counts are not normalized yet vargenes_method = 'vst', # method for variable gene selection ('vst' or 'mvp') vargenes_groups = 'annotation_20230508', # metadata column specifying groups for variable gene selection topn = 2000, # number of variable genes to choose per group d = 20, # number of PCs save_uwot_path = 'toncil_full_reference_uwot' )
Cheers,
