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Can xHLA be used for HLA-typing using RNA-Seq data

Open raunaq-m opened this issue 7 years ago • 2 comments

Hi I have a large amount of RNA-Seq samples available and was wondering if I can use xHLA for typing? I was not able to find mentions of RNA-Seq data usage in the paper or on the github page.

Could you please indicate if that is possible? Thanks a lot!

raunaq-m avatar Feb 26 '18 17:02 raunaq-m

@raunaq-m We have not tried it on RNA-Seq, only WGS and WES. It most likely wouldn't work for RNA-Seq since there could be allelic imbalances at the HLA loci.

tanghaibao avatar Feb 27 '18 02:02 tanghaibao

Hi, how about amplicon sequencing data for a specific HLA locus?

icymiktreize avatar Mar 13 '18 23:03 icymiktreize