Changing the grid size after creating an axis

[RomanCLV]

Hello, I just started using Pyplot and I read this article (https://www.python-graph-gallery.com/194-split-the-graphic-window-with-subplot) about axis placement. If I create a 2x2 graph with two axes, like this: plt.subplot(221) plt.subplot(223)

I am wondering how can i change from 2x2 to 2x1, in a second time (for instance, an event's callback), to have something like this:

So I start with this:

'o' are axis ; '_' are empty space __ | o _ |
| o _ |

... do some actions ...

and I finish with this: __ | o | | o |

Thanks for your time :)