Scale or not scale be more suitable for computation of SEACells?

[NPTL1201]

Dear investigators,

First of all, thank you for developing such a great tool! I read the SEACell_computation.ipynb manual carefully and found that the input for computing SEACells are being normalized but not scaled. I tried both (with and without scaling) and so far, I have not found any advantages or disadvantages regarding which to use. Do you have any recommendations on this?

Many thanks in advances,

Anlin