VB is most likely to challenge Python's position.

[benyuz]

Over the years, it has been proven that C# can neither surpass Java nor come close to Python. A dual-language strategy could be adopted: continue to maintain C# while revitalizing the VB family to counter Python's dominance.

The VB family boasts four core advantages to challenge Python's position:

• Historical Legacy: Proven track record of success in office automation. ​
• Terminal Advantage: Microsoft Office as an irreplaceable "core battlefield". ​
• User Base: Hundreds of millions of Office users and millions of VBA developers. ​
• Philosophical Alignment: Natural language, ease-of-learning and use—features that see exponentially growing value in the AI era.