The consistency of 5mC methylation generated by DeepMod and DeepMod2

[qiuyixmm]

Hello, Thanks for your great efforts to develop a series of useful tools detecting methylation across the genome, including DeepMod and DeepMod2. The first question is: do you assess the consistency of 5mC results produced by DeepMod and DeepMod2？ I have two datasets. The first was basecalled by Albacore software and 5mC methylation calling was performed by DeepMod. The second one was basecalled by Guppy and then 5mC methylation calling was performed by DeepMod2. The differences can be attributed to the biological significance or only software bias if different 5mC methylation results were detected.