Facebreaker
I was try to compare the DPS of my build with a facebreaker and two-handed variants and was feeling like the numbers for the facebreakers were skewed and noticed the the facebreakers were taking the more multiplier for physical from 172% to 2352% with an 800% facebreaker which was making a huge difference in my numbers. I could be wrong on how the calculation is done but it seems wrong to me. I have included a screen shot of my dps calc with and without the facebreakers below.

This isn't really an issue with PoB's calculations but more with how it passes information to the user clearly (or in this case unclearly). To be clear before I start explaining, PoB is doing nothing wrong.
So one thing I want to point out is in your own example with Facebreakers removed the problem your describing is still happening just on a much smaller scale. 15+49+59 does not equal 172. But that's ok because that's just not how More modifiers are calculated and that's where the confusion comes in.
Here's the real formula: (1+.15)*(1+.49)*(1+.59) which equals 2.72. Which in turn is 100% (the amount of damage you normally do) +172% damage (The amount of more damage all More modifiers are giving you). The formula for this math comes from the wiki: https://pathofexile.gamepedia.com/Stat#more_vs_increased
To double check to see if the Facebreakers calculation is correct we can do the formula again (1+.15)*(1+.49)*(1+.59)*(1+8) which equals 24.52. Which in turn is 100% (the amount of damage you normally do) +2352% (the amount of more damage all More modifiers are giving you).
And hey!!! the numbers match PoB. I hope this helps.