Problem about deconvolution_fit_SV()?

[edceeyuchen]

Here is my error: Error in solve.default(CtC) : system is computationally singular: reciprocal condition number = 1.4343e-22 And this is my code: SVsignatures_exp <- deconvolution_fit_SV(vcf = SV.vcf, input_data = SV_input$mut_props, input_signatures = SV_denovo_sigs, sig_cols = SV_cols, threshold = 6, plot = TRUE, resdir = resdir) It's bother me ! Expecting a reply!