Models used for DA and binomial outcomes

[aimirza]

What statistical tests do you use for DA at each taxon between 2 groups to test for significance? Where a taxon is the explanatory variable and the two groups are the outcome variable. For example, do you use Logistic regression via glm? IF you use logistic regression, it it possible to get the log odds ratio similar to the output from glm(..., family="binomial")?

[Maggie8888]

You may refer to the link https://bioconductor.org/packages/release/bioc/vignettes/ANCOMBC/inst/doc/ANCOMBC2.html for more detailed explanation. We did not use glm framework.