Benchmark-Models-PEtab
Benchmark-Models-PEtab copied to clipboard
Add Hoepfl_PLOSComputBiol2025
Integrated mathematical and experimental modeling uncovers enhanced EMT plasticity upon loss of the DLC1 tumor suppressor
https://doi.org/10.1371/journal.pcbi.1013076
PEtab files available online.
A few points to consider here
- The authors created the
CBSDmodel by extending theCBSmodel from literature, and used a combination ofCBSsimulations and new experimental data to calibrate theCBSDmodel. - The model is first "equilibrated" using a separate condition, and then stimulated with TGFb. This is not implemented as a PEtab
preEquilibrationCondition. Equilibration is constrained to 100 time units, and there are PEtab measurements (fromCBSsimulation) for that condition.
The second point could be addressed either using an SBML event, or the upcoming timecourses.